Other reactions that have been reported with isosorbide mononitrate modified release tablets include tachycardia, vomiting, diarrhoea, vertigo and heartburn These symptoms generally disappear during long-term treatment. Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. They occur mainly in the early stages of treatment. ![]() Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%).Īdverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified release tablets, but at a frequency no greater than for placebo. Headache predominates (up to 30%) necessitating withdrawal of 2 to 3 % of patients, but the incidence reduces rapidly as treatment continues. The adverse reactions which follow have been reported in studies with isosorbide mononitrate: The net effect when administering isosorbide mononitrate is therefore a reduced workload for the heart and an improvement in the oxygen supply/demand balance of the myocardium. By reducing the end diastolic pressure and volume, isosorbide mononitrate lowers intramural pressure, hence leading to an improvement in the subendocardial blood flow. Isosorbide mononitrate reduces the workload of the heart by producing venous and arterial dilation. Isosorbide mononitrate is an active metabolite of isosorbide dinitrate and exerts qualitatively similar effects. ![]() Research on Isosorbide mononitrate as a cervical ripener to reduce time at hospital to birth is supportive. ![]() Isosorbide mononitrate is used to for the the prophylactic treatment of angina pectoris that is, it is taken in order to prevent or at least reduce the occurrence of angina. It is sold by AstraZeneca under the trade name Imdur. Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |